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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Thirty-six Chinese brands have made it onto the list this year. Among them, eight are in the top 100, including the State Grid Corporation of China (36), the Industrial and Commercial Bank of China (ICBC) (40), Tencent (43), China Central Television (CCTV) (62), Haier (76), China Mobile (79), Huawei (81) and Lenovo (90).
单词consciousness 联想记忆:

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

10月,政府宣布准备终结数十年之久的“独生子女政策”。此项政策限制了已婚夫妇的孩子人数。新规定要到明年才会生效。
中国力争达成自己的亚太区协议

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

《佛罗里达乐园》

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 广州番禺经济技术开发区正式设立
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

单词circulate 联想记忆:

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

1月份出口同比下滑6.6%至1.14万亿元人民币,而此前在去年12月份则曾增长2.3%。经济学家原本预计会增长3.6%。这是自去年7月下滑8.9%以来,出口出现的最大跌幅。
Strengthening the all-around improvement of government
Banks just cannot afford to keep up. At Goldman Sachs, for example, net revenues have dropped about a third since 2009, beaten down by structural shifts in trading and new rules crimping risk-taking. The bank tries to keep its pay ratio stable, so that means smaller total packages for the typical employee.
4.闻疾病的鼻子

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 揭秘欧司朗照明战略路线规划
Perspective

Trends and targets in antiviral phototherapy

17. Most Complex Hurdle As of Dec. 7, seven out of 20 domestic top-grossing movies released this year had female-driven stories, according to the website Box Office Mojo. By contrast, five out of 20 female-driven stories topped the international market, which accounts for some 70 percent of the industry’s revenue. This may look bad, but the numbers appear marginally better than they have in recent years.
?根据市长迈克尔?布隆伯格,报道的33个事故有10个发生在纽约,数字还有望上升。纽约的死亡是由于倒下的树木、电击和溺水。
Remedy: While the idea of being your own boss is an attractive one, not everyone is cut out to be an entrepreneur. Being responsible for your own success, creating a legacy for your family and improving the lives of clients and customers certainly sounds romantic, but what about the long hours, the lack of leisure time, the risk of financial failure, the fact that you’re the boss, entry-level employee, marketer, accountant and janitor all rolled into one? If you value job stability, prefer a singular focus over multi-tasking, aren’t particularly comfortable with risk and can’t imagine yourself hustling for new business on a daily basis, the entrepreneurial lifestyle isn’t for you.
Gymnastics;Trampoline;Artistic gymnastics;Rhythmic gymnastics

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

So, before the world gets the better of you and slaps a title on your forehead, create a unique manifesto of what you think you are.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

否则,就应该交易考辛斯还有在过去的两个赛季里签下的其他的老将了。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

With best wishes for a happy New Year!
At the end of a politically charged ceremony in which Donald Trump was the subject of frequent jokes by host Jimmy Kimmel, Warren Beatty and Faye Dunaway announced that La La Land had won. But as the producers and cast of Damien Chazelle’s modern musical were on stage giving emotional thank you speeches, they were told that Moonlight was the real winner.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

特斯拉(Tesla) Model 3s的产量会超过25万辆吗?
她向BBC透露称:“他们看到了一些非常可怕的事情,但是他们将在很长一段时间内继续接触这类事情。”

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

揭露好莱坞流氓的女星发起了MeToo行动,意在揭露高层性侵女性事件,表示性侵者都是“失败者”。
"If it (transforming the economic development mode) only results in empty talk instead of being implemented, then economic development cannot be promoted in a sound and rapid way, and may even not be sustained." LI YIZHONG, member of the CPPCC National Committee and former minister of industry and information technology

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

坚决打好蓝天保卫战。
Sure, it plays music, has a calendar, and even entertains the kids, but it could probably also get hacked — just like everything else.
She says she noticed the similarities between her and the Disney character when she first saw the film in December, calling the experience eerie.
其中,国产动作片《战狼2》位居榜首,成了中国史上收入最高的影片,门票销售狂揽56.8亿元。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 温州万全将建国际家居直销中心
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

The 500 brands come from 28 different countries, among which nearly half, 227, are from the US.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

n. 按揭,抵押贷款
Tomorrow Never Dies gets the other honorable mention on our James Bond theme song list.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

美国当地时间3月23日,由尼克森电视台举办的第26届儿童选择奖颁奖礼在加州洛杉矶的南加大体育中心举行。好莱坞女星克里斯汀·斯图尔特身着蓝色连体裤出席,大秀美腿。在颁奖典礼上斯图尔特先是凭借着《暮色》系列终结篇《破晓(下)》摘得了最受欢迎电影女演员奖。之后又再次凭借电影《白雪公主与猎人》夺得了最受欢迎女动作影星的宝座,成为了本次颁奖礼上唯一一个独揽双奖的明星。当颁奖嘉宾宣布斯图尔特获奖时,她从座位上站起前往领奖台,一路上被孩子们“围攻”以致差点摔倒。由此可见孩子们对这位女星的喜爱程度了。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Insecure

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

据中国新闻报道,在2011此墓主人被认定为刘非(公元前169-127),汉朝诸侯国江都第一任国君。
Over at Huffington Post Mark Gongloff warns: That 'dramatic downgrade of U.S. economic growth in the first quarter revealed the economy's lingering weakness, exposed the folly of Washington's austerity obsession and slapped the Federal Reserve's newfound optimism right in the face.' And with politics deteriorating, it'll get worse.
他在一则电话采访中向汤森路透基金会透露:“外出打工应该只是一个选择。但是对于2亿人来说,却是没得选择的选择。”
特斯拉(Tesla) Model 3s的产量会超过25万辆吗?

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

美国在2014年的新增工作岗位被设定为300万个—这是自1999年以来最大的增加量。新增工作岗位的增加预计在2015年将会对得到持续,这将确保消费者支出得到持续的动力;同时汽油价格的下降也将为家庭支出节省额外的开支用以购买其他的商品和服务。详见:汽油价格在2014年下降美国将会节省140亿美元开支。
D'ALOISIO BEGAN designing iPhone apps nearly the moment the app store opened in 2008. He was 12 years old, working on a Mac in his bedroom in the London district of Wimbledon. Because he was too young, he signed up for the Apple developer's license using his father's name. He'd taken no formal computer science classes at school, and neither of his parents (Diana and Lou, a lawyer and a business executive, respectively) knew much about tech. Instead, he learned how to program almost entirely by himself, scouring websites and watching instructional videos.
目前还不清楚拉格菲尔德离世之后将由谁来照顾邱佩特。
Granted, it is easier to remake something than to make something new. Anyone who has faced a blank page knows that. But if fashion’s ubiquitous default to the 1960s over the last seven years has exposed anything, it is its own lack of imagination, not only about clothes and consumers, but about the relationship of culture and dress.
Chinese mainland is home to two of the top three universities in Asia, according to research published last Thursday by the Times Higher Education (THE).

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

“中国是澳大利亚最有价值的旅游市场,到2020年其价值可能超过130亿美元。”
赢家:鹈鹕

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 保定17宗地块挂牌出让
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Due to the rapid growth of the online gaming sector, NetEase founder Ding Lei doubled his wealth to 96 billion yuan, surpassing Baidu Inc Chairman Robin Li and ranking third in the IT rich list.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Morgan Slain, CEO of SplashData said: "Seeing passwords like 'adobe123' and 'photoshop' on this list offers a good reminder not to base your password on the name of the website or application you are accessing.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

n. 经营方法,行为态度
[?'ridnl]
10. Knighted Penguin
The unemployment rate has plunged over the past three years to 5.8% from 8.6%, but almost nobody, including the Federal Reserve, thinks the labor market is really that healthy.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 家居电商化须探“特色”之路
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

British golden girl, Lily Donaldson - who has been a cover girl for the likes of Vogue - showcased her own sultry take on summer style, wearing a white semi-sheer, strapless dress to the event. The 30-year-old model looked simply sensational in the nearly transparent number.
这句话是唯一来自现实世界而不是网络的。一位政府官员在回答《焦点访谈》记者“天津市每年要偿还公路建设的贷款量有多大”的问题时,回答到“这事儿不能说太细”,网民们觉得这句话很有意思,于是流传甚广。
But John Davies, head of institutional investment in the Hong Kong team at CBRE, the property services business, says that lower prices should make the market more reliable. “The market is showing characteristics of a mature market, which institutional investors understand better,” he says.
截至2016年底,中国仍有4300万农村地区的人口生活在贫困状态下。中国的目标是在2020年时帮助他们脱贫。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Lufax is the largest, a subsidiary of China’s Ping An Insurance, which is Lufax’s largest shareholder.
vt

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

寄希望于电梯可能会再度恢复运行,他随即按下所有楼层的按钮,但是并没有奏效。于是,孙轶潇按下"停止"按钮,锁住电梯,确保不会再下坠。
She's the perfect choice for this role, having hosted the Oscars last year, and previously hosted the Grammy Awards and the Primetime Emmys.
在周某投毒之后,他的一名唐姓同学发现了饮水机的水呈乳白色,还有一股刺鼻的气味。
奥巴马的另两条上榜推文是在他卸任时发布的。
4.You Don't Like Most of Your Coworkers

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

《患难与共》(Togetherness),HBO,1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人(《都市女孩》[Girls]第四季第一集将在同一天晚上播出),还有快到30岁的旧金山男同性恋(《寻》[Looking]也在当天开播第二季)。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass),兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻,和杜普拉斯最好的朋友(史蒂夫·齐西斯[Steve Zissis]饰演)与林斯基的姊妹(阿曼达·皮特[Amanda Peet]饰)合住一栋房子。
*Guest Actor in a Drama Series: Hank Azaria, “Ray Donovan”
n. 硅

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

提供公务员考试培训的教育机构中公网校的数据显示,报名首日共有31220人通过审核,超过去年同期的2.5万人。
故事发生在《海底总动员》第一部结束的一年后,多莉展开了一场全新的海底冒险:寻找自己的父母。在这部史诗巨制中,多莉沿加利福尼亚海岸的冒险之旅,得到了尼莫和马林的鼎力相助。 故事中也将迎来一批全新的角色。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Audrey Zhang, a fifth-grader from Levittown, N.Y., is the winner of this year's Doodle 4 Google competition, rising to the top of some 100,000 entries on the theme of "draw one thing to make the world a better place."
Female founders in Silicon Valley will raise more money next year, as sexual harassment scandals have forced investors to rethink their habit of backing ventures founded by mainly young, white men. Some start-ups founded by men pursued by rumours of unsavoury pasts will not get funding, even if they are a good investment proposition.
You can browse the full list at AskMen.com. Here are the top 10 women:

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

*Guest Actor in a Drama Series: Hank Azaria, “Ray Donovan”
对家长而言,整天抱着孩子非常费劲,尤其是孩子越来越大、越来越重的时候。
The gig economy

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

[h?b]

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Chinese direct investment in the eurozone was up 37 per cent in 2015, rising to $17.1bn from $12.5bn.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

答:这是我第一次去旧金山。非常美丽的城市。到那儿的第一天我们就去看了金门大桥。海湾的景色真是让人愉悦啊。我在日本每次看电影,这个城市和这个桥都要被毁一次。但我从不知道这个城市亲眼看的话居然有这么美。下次再来可能就没机会看这座桥了,所以我很高兴这次能看到。
Skyfall Bond girl Berenice Marlohe has joined the all-star cast of Terrence Malick’s latest movie, which is in production in Austin.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 高档小区怎敢“雨污不分离”?
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

So what does 2015 portend? Here are some educated guesses.
A few years back, a flying bicycle called the "Paravelo" was invented. And it isn't called a flying bicycle for fun. It is a bicycle (with a large parachute on top) that actually flies. It travels around 25 kilometers per hour (15 mph) on land and 40 kilometers per hour (25 mph) in the air. It can also fly up to a height of 1,200 meters (4,000 ft). The best part? You don't need a pilot's license. The Paravelo has been called the world's first flying bicycle, a title we must point out it does not really own.
Brands with the most to make up for in 2015:Volkswagen, whose stale product line depressed sales by 11%, thereby delaying Ferdinand Piech’s plans for global supremacy, and Volvo, down 17%, which has yet to make any progress under its Chinese owner.
同时,只有三部好莱坞大片成功挤进2015年中国电影票房销售额的前十名。它们分别是《速度与激情7》、《复仇者联盟:奥创纪元》以及《侏罗纪世界》。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 2015年中国石材十大品牌企业排名
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Manohla Dargis
经济衰退可能已有所好转,但是距离就业市场的复苏还有很长一段路要走。并且专家也声称情况在好转之前可能先会恶化。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 家居卖场开春首个“促销季”来临
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

19. Going, Going, Almost Gone Quentin Tarantino shot his latest, “The Hateful Eight,” in 70 millimeter, and the film is slated to play in almost 100 theaters that, like most of rooms across the country, now usually use digital projection. Whatever you think of Mr. Tarantino, try to catch “The Hateful Eight” on film so you can see for yourself how the industry-enforced switch to digital has radically changed movies.
该书作者马丁輠祹(Martin Ford)周二在纽约的颁奖典礼上获得了英国《金融时报》和麦肯锡(McKinsey & Company)颁发的3万英镑奖金。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

库迪斯和沃斯在孜孜不倦分析荷兰金融记录的过程中得出了结论,悲观者和乐观者之间真正的区别在于他们是否亲身经历过这样的痛苦过程。库迪斯认为,可以类比的是那些经历过大萧条的人们的行为:这些人在大萧条梦魇过去后的几十年里,一直回避金融风险。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

韩国全州——在全州的韩屋村,仍保留着几百座传统的韩式房屋。
The disclosure form also warns forex buyers that they are not allowed to exploit others’ exchange quotas. Previously, aggregating quotas from multiple individuals was a common technique that grey-market money changers used to obtain large sums of foreign exchange.
X
China will not overreach its regional influence to seek trade arrangements where the country's due role is not in place.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

泡沫气球
[sp?n'teini?s]

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 钢铁业低迷:亏损企业常年不倒
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

但来自宾夕法尼亚州(Pennsylvania)的玛蒂?齐格勒(Maddie Ziegler),她的人生完全不是这么一回事。
But this has begun to feel less like a relevant statement about what women want now and more like a retreat; an assumption, which I would characterize as false, that the past is a safe place to dress.
专家警告说,在普通词汇中添加数字或符号根本没用。斯莱恩说:“黑客们都知道你的小伎俩,对容易破解的密码稍作调整不会更安全。”

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

(G.I. Joe: Retaliation)以及两部小规模电影,加起来在全球的票房收入总计13亿美元。
The new data released yesterday represent the first snapshot of global trade for 2015. But the figures also come amid growing concerns that 2016 is already shaping up to be more fraught with dangers for the global economy than previously expected.
冲击奖项:如果这届奥斯卡最佳影片的提名数有9或10部电影的话,那么《逃出绝命镇》能占一个。乔登皮尔的剧本应该一定会被提名。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

万圣节距离现在没几天了。这意味着,如果你还没有挑选好你的万圣节服装或者装饰,那你应该立刻开始准备了。
Indeed, everyone from Jennifer Garner, to January Jones and Kylie Jenner have been photographed as they pick out their most spook-worthy pumpkins in time to send October out with a thrill.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 木材家具业或迎新一轮涨价
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

一,中国航空发动机集团的成立。去年集团公司通过研发提高了国产发动机的技术水平与续航能力,表明自主开发飞机发动机仍是当前中国的战略重点。当中国获得了铼,一种制造高压喷气发动机涡轮叶片的必须合金材料之后,这一决心更加显著。2010年在陕西发现占世界总储量7%的铼矿后,中国已投入相当大的精力开采并应用这一金属。此外,现代喷气发动机的关键部件——大规模单晶涡轮叶片制造技术也取得了重大突破。新成立的中俄宽体客机项目至此有望用上国产发动机。
The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.
The sales volume peaks at around 15 million per day, with nearly 700 tickets sold in every second.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

达奇斯说:2011年达美乐的品牌热情大幅度增长,但是2012年无法与之相提并论。他们不能每年都重新设计食谱,真是太可惜了。
"It is my belief that due to their lack of ability to curve cheat codes and others from modifying their game, they are using a 14-year-old child as a scapegoat to make an example of him," she said.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 智能家居缺乏统一标准成发展瓶颈
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

来自荷兰的Anita Eerland和Rolf Zwaan,以及来自秘鲁的Tulio Guadalupe被授予心理学奖,其研究题目是《向左倚靠会让埃菲尔铁塔看上去更小一些》。
负责2012伦敦奥运会国际游客接待的8000名志愿者,收到了一份长达66页的指南手册,里面包含了大小事项,从国外礼节到着装细节再到如何和记者打交道。可是外国游客们的指南在那里呢?没有指南手册告诉他们即将游览的英伦三岛的习俗、礼仪和其他事项,他们能行吗?为了2012伦敦奥运会,我们下面就来简单介绍一下外国游客在奥运会期间的伦敦生存指南。
Effective email marketing involves more than occasionally blasting out a newsletter. To build an effective email marketing strategy, you need a tool packed with functionality. MailChimp seems to be the best system out there, offering elegant, intuitive newsletter templates, advanced list segmentation features and marketing automation capabilities.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

西藏自治区计划到2017年帮助至少13万农村人口脱贫,重新安置16.3万人。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 敢为人先 粤派房企引领潮流
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

In the foreseeable future, China will see the boom of enterprises in tertiary industry. Related majors, including law, journalism and communication, and management, are expected to play a bigger role, according to the report.
Murietta belonged to a gang known as the Five Joaquins, who were notorious bandits during the height of the California Gold Rush. While Murietta's criminal activity likely did not have any political undertones, he nonetheless became a symbol of Mexican resistance as American settlers ventured to California. Unfortunately for him, this pushed the government to put a bounty on his head, leading to his murder and beheading. Luckily, Banderas's character didn't fall to the same fate.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

“当前是经济动荡时期,但我们看到中国企业满怀信心地行动,继续在欧洲和北美做出大动作,”他说。
考试之前,网友通过社交软件,将考试中将要出现的问题和答案截图发布出来。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

早先一个由活动分子和美国人权基金在一月份投放100000份电影的计划被推迟到了上个月的新年后。
Gov. Ricardo Rossello, 37, proposed several measures aimed at alleviating the crisis shortly after he was sworn in at midnight. Among them is a proposal to hold a referendum that would ask voters whether they prefer statehood or independence. Many have argued that Puerto Rico’s political status has contributed to its decade-long crisis that has prompted more than 200,000 people to flee to the U.S. mainland in recent years.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

中国的创新表现有所改善,在"创新质量"方面排名第17,这是个考量高校水平、科学出版物数量和国际专利申请量的指标。
Paddington 2

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

China's National Bureau of Statistics said its property prices index for November showed that new home prices fell 3.7 per cent from a year ago, the third straight annual decline following readings of -2.6 per cent in October and -1.3 per cent in September.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

em进入,brace胳膊-拥抱
The Best Global Universities rankings are based on data and metrics provided by Clarivate Analytics InCites.
After working for half a year, the average monthly income for 2014 graduates is RMB3,487, a significant increase from RMB3,250 in 2013 and RMB3,048 in 2012.
5.匈牙利德布勒森

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Under the Skin is just so visually free and uninhibited that there is an intense dark, destructive sexiness in everything about it – quite apart from the hilarious, bizarre, mesmeric eroticism of the film itself. It is a work of subcutaneous potency. It gets under your skin.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

A total of 61 IPOs were launched on the Shanghai and Shenzhen stock exchanges, down 67 percent on the same period last year. About 28.8 billion yuan (4.3 billion U.S.dollars) was raised, down by 80 percent.
许多分析师或许会对有关他们低估美联储的说法感到愕然。如今人们在谈论新兴市场资产时,最常提到的两个相关因素就是美联储和中国,以及它们将来造成负面冲击的风险。
《为奴十二年》导演史蒂夫?麦奎因(Steve McQueen)在登台领奖时说:我有点吓到了。然后他微微耸肩,引用片中福音歌曲的歌词,说了句“翻涌吧,约旦河,翻涌吧”("Roll, Jordan, roll")。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

在20世纪90年代,罗斯把它应用到如何把美国医学生分配到医院。他开发了一种新的算法被全国驻地医师匹配程序所采用,这有助于把驻院医师分配到合适的医院。
《拉里·威尔莫夜间秀》(The Nightly Show with Larry Wilmore),Comedy Central,1月19日播出。威尔莫的主题喜剧秀将取代《科尔伯特报告》(The Colbert Report)在夜间11:30播出,这是深夜节目多样化的最新尝试。完全没有压力!

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Artificial pancreas, however, knock insulin into your body automatically. The device looks much like a regular insulin pump, which slips you insulin continuously through your skin, but this one monitors your blood sugar at all times and adjusts itself accordingly. So even when the wearer sleeps, there's no danger of falling into shock if their sugar drops too low.
adj. 可用的,可得到的,有用的,有效的

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

10. Run the Jewels “Run the Jewels 2” (Mass Appeal) Speaking of urgent and stinging, Killer Mike and El-P, veteran underground rappers from different scenes, found firm traction on their second round as Run the Jewels. Their flow is strong and their focus is furious on an album that calls out power structures but lets nobody off the hook.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

这份榜单的四所英国大学分别是剑桥大学、牛津大学和伦敦大学和帝国理工学院。东京大学也位列前20名。
《佛罗里达乐园》
6.癌症死亡率

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

6.微型人脑
对于购房者,也不都是坏消息:房价明年(2015年——译注)仍将上涨,但步伐可能会从飙涨趋于平缓。“房价不会一味地陡然上涨,”柯克兰集团(Corcoran)的首席执行官帕梅拉·利伯曼(Pamela Liebman)说,“买家都有点疲劳了。”
在即将卸任的中国领导层不愿做出任何有远见的决定时,中国必须沿着一条狭窄的道路审慎推进。
第一次出现在人体内。禽类可能是病毒来源。Appeared for the first time in humans. It caused illness in two children in Hong Kong, with poultry being the probable source.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

今年夏季,美国ETF管理的资产规模跨过3万亿美元大关,亚太ETF行业管理的资产仅成功爬上3500亿美元关口。
For the fifth year in a row the city-state's Changi Airport has been named "world's best airport" at the annual Skytrax World Airport Awards.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The unemployment rate has plunged over the past three years to 5.8% from 8.6%, but almost nobody, including the Federal Reserve, thinks the labor market is really that healthy.
报告显示,与2015年相比,2016年选择创业的应届毕业生比例明显下降,由6.3%降至3.1%。
The studio says it has taken the step because the boy declined to remove a YouTube video he published which promoted how to use the software.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 广东确保完成“大棚房”整治任务
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《中国日报》(China Daily)援引中国旅游研究院(China Tourism Academy)和北京市旅游发展委员会(Beijing Commission of Tourism Development)的一篇报告称,污染状况加剧以及人民币升值,使得北京去年1月至11月间的外国游客数量从2012年同期的501万人下降至420万人。此前一份基于对国内旅行社的调查的报告显示,去年前三个季度赴北京旅游的游客数量较上年同期下降约50%。
The results are based on a survey of 15,870 people across the country in August and September.

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